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pgx-main from prod added

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Darren Wight
2025-08-18 12:06:58 +02:00
parent fcb0e9aa4c
commit fe48df8676
984 changed files with 878657 additions and 0 deletions
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CYP2D6 *15/*17
1 CYP2D6 *15/*17

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name genotype phenotype genotype_description lookupkey subgroups
ABCG2 rs2231142 reference (G)/rs2231142 reference (G) Normal Function Two normal function alleles Normal Function ABCG2:Normal Function
CFTR ivacaftor non-responsive CFTR sequence/ivacaftor non-responsive CFTR sequence ivacaftor non-responsive in CF patients Diagnosed with cystic fibrosis (cf) and negative for a cftr variant listed in the fda-approved drug label as being responsive to ivacaftor ivacaftor non-responsive in CF patients CFTR:ivacaftor non-responsive in CF patients
CYP2B6 *1/*6 Intermediate Metabolizer One normal function allele and one decreased function allele Intermediate Metabolizer CYP2B6:Intermediate Metabolizer
CYP2C19 *17/*38 Rapid Metabolizer One normal function allele and one increased function allele Rapid Metabolizer CYP2C19:Rapid Metabolizer
CYP2C8 *1.001/*1.001
CYP2C9 *1/*1 Normal Metabolizer Two normal function alleles 2 CYP2C9:Normal Metabolizer
CYP3A4 *1/*1
CYP3A5 *1/*1 Normal Metabolizer Two normal function alleles Normal Metabolizer CYP3A5:Normal Metabolizer
DPYD Reference/Reference Normal Metabolizer Two normal function alleles 2 DPYD:Normal Metabolizer
HLA-A reference/reference *31:01 negative An individual carrying no copies of the HLA-A*31:01 allele *31:01 negative HLA-A:*31:01 negative
HLA-B reference/reference *15:02 negative An individual carrying no copies of the HLA-B*15:02 allele *15:02 negative HLA-B:*15:02 negative
HLA-B reference/reference *57:01 negative An individual carrying no copies of the HLA-B*57:01 allele *57:01 negative HLA-B:*57:01 negative
IFNL3 rs12979860 reference (C)/rs12979860 variant (T)
NAT2 *14/*4 Rapid Acetylator An individual carrying at least one rapid acetylator allele NAT2:Rapid Acetylator
NUDT15 *1/*1 Normal Metabolizer Two normal function alleles Normal Metabolizer NUDT15:Normal Metabolizer
RYR1 Reference/Reference Uncertain Susceptibility Negative for a ryr1 malignant hyperthermia–causative variant as designated by the emhg. Uncertain Susceptibility RYR1:Uncertain Susceptibility
SLCO1B1 *1/*1 Normal Function Two normal function alleles Normal Function SLCO1B1:Normal Function
TPMT *1/*1 Normal Metabolizer Two normal function alleles Normal Metabolizer TPMT:Normal Metabolizer
UGT1A1 *80/*80 Poor Metabolizer Two decreased function alleles Poor Metabolizer UGT1A1:Poor Metabolizer
VKORC1 rs9923231 reference (C)/rs9923231 reference (C)
CYP2D6 *15/*17 Intermediate Metabolizer One decreased function allele with an activity value of 0.5 or a duplication of a decreased function allele with an activity value of 0.25 and one no function allele 0.5 CYP2D6:Intermediate Metabolizer
1 name genotype phenotype genotype_description lookupkey subgroups
2 ABCG2 rs2231142 reference (G)/rs2231142 reference (G) Normal Function Two normal function alleles Normal Function ABCG2:Normal Function
3 CFTR ivacaftor non-responsive CFTR sequence/ivacaftor non-responsive CFTR sequence ivacaftor non-responsive in CF patients Diagnosed with cystic fibrosis (cf) and negative for a cftr variant listed in the fda-approved drug label as being responsive to ivacaftor ivacaftor non-responsive in CF patients CFTR:ivacaftor non-responsive in CF patients
4 CYP2B6 *1/*6 Intermediate Metabolizer One normal function allele and one decreased function allele Intermediate Metabolizer CYP2B6:Intermediate Metabolizer
5 CYP2C19 *17/*38 Rapid Metabolizer One normal function allele and one increased function allele Rapid Metabolizer CYP2C19:Rapid Metabolizer
6 CYP2C8 *1.001/*1.001
7 CYP2C9 *1/*1 Normal Metabolizer Two normal function alleles 2 CYP2C9:Normal Metabolizer
8 CYP3A4 *1/*1
9 CYP3A5 *1/*1 Normal Metabolizer Two normal function alleles Normal Metabolizer CYP3A5:Normal Metabolizer
10 DPYD Reference/Reference Normal Metabolizer Two normal function alleles 2 DPYD:Normal Metabolizer
11 HLA-A reference/reference *31:01 negative An individual carrying no copies of the HLA-A*31:01 allele *31:01 negative HLA-A:*31:01 negative
12 HLA-B reference/reference *15:02 negative An individual carrying no copies of the HLA-B*15:02 allele *15:02 negative HLA-B:*15:02 negative
13 HLA-B reference/reference *57:01 negative An individual carrying no copies of the HLA-B*57:01 allele *57:01 negative HLA-B:*57:01 negative
14 IFNL3 rs12979860 reference (C)/rs12979860 variant (T)
15 NAT2 *14/*4 Rapid Acetylator An individual carrying at least one rapid acetylator allele NAT2:Rapid Acetylator
16 NUDT15 *1/*1 Normal Metabolizer Two normal function alleles Normal Metabolizer NUDT15:Normal Metabolizer
17 RYR1 Reference/Reference Uncertain Susceptibility Negative for a ryr1 malignant hyperthermia–causative variant as designated by the emhg. Uncertain Susceptibility RYR1:Uncertain Susceptibility
18 SLCO1B1 *1/*1 Normal Function Two normal function alleles Normal Function SLCO1B1:Normal Function
19 TPMT *1/*1 Normal Metabolizer Two normal function alleles Normal Metabolizer TPMT:Normal Metabolizer
20 UGT1A1 *80/*80 Poor Metabolizer Two decreased function alleles Poor Metabolizer UGT1A1:Poor Metabolizer
21 VKORC1 rs9923231 reference (C)/rs9923231 reference (C)
22 CYP2D6 *15/*17 Intermediate Metabolizer One decreased function allele with an activity value of 0.5 or a duplication of a decreased function allele with an activity value of 0.25 and one no function allele 0.5 CYP2D6:Intermediate Metabolizer

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##fileformat=VCFv4.2
##FILTER=<ID=PASS,Description="All filters passed">
##SentieonCommandLine.Haplotyper=<ID=Haplotyper,Version="sentieon-genomics-202010.04",Date="2025-04-16T17:49:16Z",CommandLine="/usr/local/share/sentieon-202010.04-0/libexec/driver -t 8 -r GRCh38_full_decoy_hla_altMasked.fa -i CAN-NA19239-29Mar2025_S32_L001.bam -q CAN-NA19239-29Mar2025_S32_L001_qualcal.txt --interval 1546719.bed --algo Haplotyper -d dbsnp_138.b38.vcf.gz CAN-NA19239-29Mar2025_S32_L001_single_raw.vcf.gz">
##reference=file://GRCh38_full_decoy_hla_altMasked.fa
##CL=vcffilter -i CAN-NA19239-29Mar2025_S32_L001_single_raw.vcf.gz -o CAN-NA19239-29Mar2025_S32_L001_single.vcf.gz -j default_haplotyper.js
##INFO=<ID=AC,Number=A,Type=Integer,Description="Allele count in genotypes, for each ALT allele, in the same order as listed">
##INFO=<ID=AF,Number=A,Type=Float,Description="Allele frequency, for each ALT allele, in the same order as listed">
##INFO=<ID=AN,Number=1,Type=Integer,Description="Total number of alleles in called genotypes">
##INFO=<ID=BaseQRankSum,Number=1,Type=Float,Description="Z-score from Wilcoxon rank sum test of Alt Vs. Ref base qualities">
##INFO=<ID=ClippingRankSum,Number=1,Type=Float,Description="Z-score From Wilcoxon rank sum test of Alt vs. Ref number of hard clipped bases">
##INFO=<ID=DB,Number=0,Type=Flag,Description="dbSNP membership">
##INFO=<ID=DP,Number=1,Type=Integer,Description="Combined depth across samples">
##INFO=<ID=ExcessHet,Number=1,Type=Float,Description="Phred-scaled p-value for exact test of excess heterozygosity">
##INFO=<ID=FS,Number=1,Type=Float,Description="Phred-scaled p-value using Fisher's exact test to detect strand bias">
##INFO=<ID=InbreedingCoeff,Number=1,Type=Float,Description="Inbreeding coefficient as estimated from the genotype likelihoods per-sample when compared against the Hardy-Weinberg expectation">
##INFO=<ID=MLEAC,Number=A,Type=Integer,Description="Maximum likelihood expectation (MLE) for the allele counts, for each ALT allele, in the same order as listed">
##INFO=<ID=MLEAF,Number=A,Type=Float,Description="Maximum likelihood expectation (MLE) for the allele frequency, for each ALT allele, in the same order as listed">
##INFO=<ID=MQ,Number=1,Type=Float,Description="RMS mapping quality">
##INFO=<ID=MQRankSum,Number=1,Type=Float,Description="Z-score From Wilcoxon rank sum test of Alt vs. Ref read mapping qualities">
##INFO=<ID=QD,Number=1,Type=Float,Description="Variant Confidence/Quality by Depth">
##INFO=<ID=ReadPosRankSum,Number=1,Type=Float,Description="Z-score from Wilcoxon rank sum test of Alt vs. Ref read position bias">
##INFO=<ID=SOR,Number=1,Type=Float,Description="Symmetric Odds Ratio of 2x2 contingency table to detect strand bias">
##FORMAT=<ID=AD,Number=R,Type=Integer,Description="Allelic depths for the ref and alt alleles in the order listed">
##FORMAT=<ID=DP,Number=1,Type=Integer,Description="Read depth">
##FORMAT=<ID=GQ,Number=1,Type=Integer,Description="Genotype quality">
##FORMAT=<ID=GT,Number=1,Type=String,Description="Genotype">
##FORMAT=<ID=PL,Number=G,Type=Integer,Description="The phred-scaled genotype likelihoods rounded to the closest integer">
##bcftools_concatVersion=1.12+htslib-1.12
##bcftools_concatCommand=concat -a CAN-NA19239-29Mar2025_S32_L001_single.vcf.gz; Date=Wed Apr 16 17:50:47 2025
##contig=<ID=chr1,assembly=GRCh38.p13,species="Homo sapiens">
##contig=<ID=chr2,assembly=GRCh38.p13,species="Homo sapiens">
##contig=<ID=chr3,assembly=GRCh38.p13,species="Homo sapiens">
##contig=<ID=chr4,assembly=GRCh38.p13,species="Homo sapiens">
##contig=<ID=chr5,assembly=GRCh38.p13,species="Homo sapiens">
##contig=<ID=chr6,assembly=GRCh38.p13,species="Homo sapiens">
##contig=<ID=chr7,assembly=GRCh38.p13,species="Homo sapiens">
##contig=<ID=chr8,assembly=GRCh38.p13,species="Homo sapiens">
##contig=<ID=chr9,assembly=GRCh38.p13,species="Homo sapiens">
##contig=<ID=chr10,assembly=GRCh38.p13,species="Homo sapiens">
##contig=<ID=chr11,assembly=GRCh38.p13,species="Homo sapiens">
##contig=<ID=chr12,assembly=GRCh38.p13,species="Homo sapiens">
##contig=<ID=chr13,assembly=GRCh38.p13,species="Homo sapiens">
##contig=<ID=chr14,assembly=GRCh38.p13,species="Homo sapiens">
##contig=<ID=chr15,assembly=GRCh38.p13,species="Homo sapiens">
##contig=<ID=chr16,assembly=GRCh38.p13,species="Homo sapiens">
##contig=<ID=chr17,assembly=GRCh38.p13,species="Homo sapiens">
##contig=<ID=chr18,assembly=GRCh38.p13,species="Homo sapiens">
##contig=<ID=chr19,assembly=GRCh38.p13,species="Homo sapiens">
##contig=<ID=chr20,assembly=GRCh38.p13,species="Homo sapiens">
##contig=<ID=chr21,assembly=GRCh38.p13,species="Homo sapiens">
##contig=<ID=chr22,assembly=GRCh38.p13,species="Homo sapiens">
##contig=<ID=chrX,assembly=GRCh38.p13,species="Homo sapiens">
##contig=<ID=chrY,assembly=GRCh38.p13,species="Homo sapiens">
##contig=<ID=chrM,assembly=GRCh38.p13,species="Homo sapiens">
##INFO=<ID=PX,Number=.,Type=String,Description="Gene">
##INFO=<ID=POI,Number=0,Type=Flag,Description="Position of Interest but not part of an allele definition">
##FILTER=<ID=PCATxREF,Description="Reference allele does not match PharmCAT reference alleles">
##FILTER=<ID=PCATxALT,Description="Alternate alleles do not match PharmCAT alternate alleles">
#CHROM POS ID REF ALT QUAL FILTER INFO FORMAT CAN-NA19239-29Mar2025_S32_L001
chr1 97078987 rs114096998 G T . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97078993 rs148799944 C G . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97079005 rs140114515 C T . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97079071 rs1801268 C A . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97079076 rs139459586 A C . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97079077 rs202144771 G A . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97079121 rs72547601 T C . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97079133 rs72547602 T A . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97079139 rs145529148 T C . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97082365 rs141044036 T C . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97082391 rs67376798 T A . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97098598 rs1801267 C T . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97098599 rs147545709 G A . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97098616 rs55674432 C A . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97098632 rs201035051 T G . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97193109 rs60139309 T C . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97193209 rs200687447 C T . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97234958 rs199634007 G T . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97234991 rs56005131 G T . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97305279 rs112766203 G A . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97305363 rs60511679 A C . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97305364 rs1801160 C T . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97305372 rs146529561 G A . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97306195 rs145548112 C T . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97373598 rs137999090 C T . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97373629 rs138545885 C A . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97382461 rs55971861 T G . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97450058 rs3918290 C T . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97450059 rs3918289 G C . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97450065 rs72549303 TG T . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97450068 rs17376848 A G . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97450168 rs147601618 A G . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97450187 rs145773863 C T . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97450189 rs138616379 C T . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97450190 rs59086055 G A . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97515784 rs201615754 C A . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97515787 rs55886062 A C . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97515839 rs1801159 T C . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97515851 rs142619737 C T . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97515865 rs1801158 C T . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97515889 rs190951787 G C . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97515923 rs148994843 C T . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97549565 rs138391898 C T . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97549600 rs111858276 T C . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97549609 rs72549304 G A . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97549681 rs199549923 G T . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97549713 rs57918000 G A . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97549726 rs144395748 G C . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97549735 rs72975710 G A . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97573785 rs186169810 A C . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97573805 rs142512579 C T . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97573821 rs764666241 C A . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97573839 rs200064537 A T . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97573863 rs56038477 C T . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97573881 rs61622928 C T . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97573918 rs143815742 C A . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97573919 rs140602333 G A . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97573943 rs78060119 C A . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97579893 rs75017182 G C . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97593238 rs72549305 T C . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97593289 rs143154602 G A . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97593322 rs183385770 C T . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97593343 rs72549306 C A . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97593379 rs201018345 C T . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97595083 rs145112791 G A . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97595088 rs150437414 A G . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97595149 rs146356975 T C . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97679170 rs45589337 T C . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97691776 rs1801266 G A . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97699399 rs72549307 T C . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97699430 rs72549308 T G . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97699474 rs115232898 T C . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97699506 rs6670886 C T . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97699533 rs139834141 C T . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97699535 rs2297595 T C . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97721542 rs200562975 T C . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97721650 rs141462178 T C . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97740400 rs150385342 C T . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97740410 rs72549309 GATGA G . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97883329 rs1801265 A G . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97883352 rs80081766 C T . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97883353 rs72549310 G A . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 97883368 rs150036960 G C . PASS PX=DPYD;AC=0;AN=2 GT 0|0
chr1 201060815 rs1800559 C T . PASS PX=CACNA1S;AC=0;AN=2 GT 0|0
chr1 201091993 rs772226819 G A . PASS PX=CACNA1S;AC=0;AN=2 GT 0|0
chr2 233759924 rs887829 C T 13571.8 PASS AC=2;AF=1;AN=2;DB;DP=453;ExcessHet=3.0103;FS=0;MLEAC=2;MLEAF=1;MQ=60;QD=30.03;SOR=0.865 GT:AD:DP:GQ:PL 1/1:0,452:452:99:13600,1356,0
chr2 233760233 rs3064744 CAT CATAT,CATATAT,C . PASS PX=UGT1A1;AC=0,0,0;AN=2 GT 0|0
chr2 233760498 rs4148323 G A . PASS PX=UGT1A1;AC=0;AN=2 GT 0|0
chr2 233760973 rs35350960 C A . PASS PX=UGT1A1;AC=0;AN=2 GT 0|0
chr4 88131171 rs2231142 G T . PASS PX=ABCG2;AC=0;AN=2 GT 0|0
chr6 18130687 rs1142345 T C,G . PASS PX=TPMT;AC=0,0;AN=2 GT 0|0
chr6 18130694 rs150900439 T C . PASS PX=TPMT;AC=0;AN=2 GT 0|0
chr6 18130725 rs72552736 A C . PASS PX=TPMT;AC=0;AN=2 GT 0|0
chr6 18130729 rs139392616 C T . PASS PX=TPMT;AC=0;AN=2 GT 0|0
chr6 18130758 rs398122996 A T . PASS PX=TPMT;AC=0;AN=2 GT 0|0
chr6 18130762 rs56161402 C T . PASS PX=TPMT;AC=0;AN=2 GT 0|0
chr6 18130772 rs377085266 A G . PASS PX=TPMT;AC=0;AN=2 GT 0|0
chr6 18130781 rs1800584 C T . PASS PX=TPMT;AC=0;AN=2 GT 0|0
chr6 18132136 rs72556347 A G . PASS PX=TPMT;AC=0;AN=2 GT 0|0
chr6 18132147 rs79901429 A G . PASS PX=TPMT;AC=0;AN=2 GT 0|0
chr6 18132163 . C T . PASS PX=TPMT;AC=0;AN=2 GT 0|0
chr6 18133845 rs75543815 T A . PASS PX=TPMT;AC=0;AN=2 GT 0|0
chr6 18133847 rs6921269 C A . PASS PX=TPMT;AC=0;AN=2 GT 0|0
chr6 18133870 rs772832951 A G . PASS PX=TPMT;AC=0;AN=2 GT 0|0
chr6 18133884 rs74423290 G C . PASS PX=TPMT;AC=0;AN=2 GT 0|0
chr6 18133887 rs201695576 T C . PASS PX=TPMT;AC=0;AN=2 GT 0|0
chr6 18133890 rs9333570 C T . PASS PX=TPMT;AC=0;AN=2 GT 0|0
chr6 18138969 rs144041067 C G,T . PASS PX=TPMT;AC=0,0;AN=2 GT 0|0
chr6 18138970 rs112339338 G A . PASS PX=TPMT;AC=0;AN=2 GT 0|0
chr6 18138997 rs1800460 C T . PASS PX=TPMT;AC=0;AN=2 GT 0|0
chr6 18139027 rs72552737 C G . PASS PX=TPMT;AC=0;AN=2 GT 0|0
chr6 18139689 rs72552738 C T . PASS PX=TPMT;AC=0;AN=2 GT 0|0
chr6 18139710 rs200220210 G A . PASS PX=TPMT;AC=0;AN=2 GT 0|0
chr6 18143597 . T G . PASS PX=TPMT;AC=0;AN=2 GT 0|0
chr6 18143606 rs151149760 T G . PASS PX=TPMT;AC=0;AN=2 GT 0|0
chr6 18143613 . C G . PASS PX=TPMT;AC=0;AN=2 GT 0|0
chr6 18143622 rs115106679 C T . PASS PX=TPMT;AC=0;AN=2 GT 0|0
chr6 18143643 . A C . PASS PX=TPMT;AC=0;AN=2 GT 0|0
chr6 18143700 rs753545734 C T . PASS PX=TPMT;AC=0;AN=2 GT 0|0
chr6 18143718 rs111901354 G A . PASS PX=TPMT;AC=0;AN=2 GT 0|0
chr6 18143724 rs1800462 C G . PASS PX=TPMT;AC=0;AN=2 GT 0|0
chr6 18143728 rs1256618794 C A . PASS PX=TPMT;AC=0;AN=2 GT 0|0
chr6 18147838 rs281874771 G A . PASS PX=TPMT;AC=0;AN=2 GT 0|0
chr6 18147845 rs777686348 C T . PASS PX=TPMT;AC=0;AN=2 GT 0|0
chr6 18147851 rs200591577 G C . PASS PX=TPMT;AC=0;AN=2 GT 0|0
chr6 18147856 . A G . PASS PX=TPMT;AC=0;AN=2 GT 0|0
chr6 18147910 rs72552740 A G . PASS PX=TPMT;AC=0;AN=2 GT 0|0
chr6 18149004 . G C . PASS PX=TPMT;AC=0;AN=2 GT 0|0
chr6 18149022 rs750424422 C T . PASS PX=TPMT;AC=0;AN=2 GT 0|0
chr6 18149032 rs759836180 C CT . PASS PX=TPMT;AC=0;AN=2 GT 0|0
chr6 18149045 rs72552742 T A . PASS PX=TPMT;AC=0;AN=2 GT 0|0
chr6 18149126 rs267607275 A G . PASS PX=TPMT;AC=0;AN=2 GT 0|0
chr6 18149127 rs9333569 T C . PASS PX=TPMT;AC=0;AN=2 GT 0|0
chr6 29945521 rs1061235 A T . PASS PX=HLA-A;AC=0;AN=2 GT 0|0
chr6 31355003 rs144012689 T A . PASS PX=HLA-B;AC=0;AN=2 GT 0|0
chr6 31464003 rs2395029 T G . PASS PX=HLA-B;AC=0;AN=2 GT 0|0
chr7 99652770 rs41303343 T TA . PASS PX=CYP3A5;AC=0;AN=2 GT 0|0
chr7 99660516 rs28383479 C T . PASS PX=CYP3A5;AC=0;AN=2 GT 0|0
chr7 99665212 rs10264272 C T . PASS PX=CYP3A5;AC=0;AN=2 GT 0|0
chr7 99672916 rs776746 T C . PASS PX=CYP3A5;AC=0;AN=2 GT 0|0
chr7 99676198 rs55817950 G A . PASS PX=CYP3A5;AC=0;AN=2 GT 0|0
chr7 99758060 rs72552794 A C,G . PASS PX=CYP3A4;AC=0,0;AN=2 GT 0|0
chr7 99758183 rs67666821 GT GTT,G . PASS PX=CYP3A4;AC=0,0;AN=2 GT 0|0
chr7 99760836 rs4986913 G A,C . PASS PX=CYP3A4;AC=0,0;AN=2 GT 0|0
chr7 99760901 rs4986910 A G . PASS PX=CYP3A4;AC=0;AN=2 GT 0|0
chr7 99760956 rs774109750 T C . PASS PX=CYP3A4;AC=0;AN=2 GT 0|0
chr7 99762047 rs4986909 G A,C . PASS PX=CYP3A4;AC=0,0;AN=2 GT 0|0
chr7 99762177 rs12721629 G A . PASS PX=CYP3A4;AC=0;AN=2 GT 0|0
chr7 99762186 rs756833413 C A . PASS PX=CYP3A4;AC=0;AN=2 GT 0|0
chr7 99762206 rs67784355 G A,T . PASS PX=CYP3A4;AC=0,0;AN=2 GT 0|0
chr7 99763843 rs2242480 C T 23091.8 PASS AC=2;AF=1;AN=2;DB;DP=797;ExcessHet=3.0103;FS=0;MLEAC=2;MLEAF=1;MQ=60;QD=29.16;SOR=1.319 GT:AD:DP:GQ:PL 1/1:0,792:792:99:23120,2375,0
chr7 99763877 rs368296206 A G . PASS PX=CYP3A4;AC=0;AN=2 GT 0|0
chr7 99763909 rs1303250043 G T . PASS PX=CYP3A4;AC=0;AN=2 GT 0|0
chr7 99763925 rs201821708 T C . PASS PX=CYP3A4;AC=0;AN=2 GT 0|0
chr7 99764003 rs28371759 A G . PASS PX=CYP3A4;AC=0;AN=2 GT 0|0
chr7 99766411 rs4646438 G GT . PASS PX=CYP3A4;AC=0;AN=2 GT 0|0
chr7 99766440 rs138105638 G A,T . PASS PX=CYP3A4;AC=0,0;AN=2 GT 0|0
chr7 99768360 rs55785340 A G,T . PASS PX=CYP3A4;AC=0,0;AN=2 GT 0|0
chr7 99768371 rs55901263 G C . PASS PX=CYP3A4;AC=0;AN=2 GT 0|0
chr7 99768424 rs113667357 T A,C . PASS PX=CYP3A4;AC=0,0;AN=2 GT 0|0
chr7 99768445 rs4987159 G A,C . PASS PX=CYP3A4;AC=0,0;AN=2 GT 0|0
chr7 99768458 rs4987161 A G . PASS PX=CYP3A4;AC=0;AN=2 GT 0|0
chr7 99768470 rs12721627 G C . PASS PX=CYP3A4;AC=0;AN=2 GT 0|0
chr7 99768693 rs35599367 G A . PASS PX=CYP3A4;AC=0;AN=2 GT 0|0
chr7 99769769 rs4986908 C G,T . PASS PX=CYP3A4;AC=0,0;AN=2 GT 0|0
chr7 99769781 rs72552798 C T . PASS PX=CYP3A4;AC=0;AN=2 GT 0|0
chr7 99769804 rs4986907 C T . PASS PX=CYP3A4;AC=0;AN=2 GT 0|0
chr7 99769805 rs57409622 G A . PASS PX=CYP3A4;AC=0;AN=2 GT 0|0
chr7 99770165 rs72552799 C G,T . PASS PX=CYP3A4;AC=0,0;AN=2 GT 0|0
chr7 99770166 rs778013004 G A,C . PASS PX=CYP3A4;AC=0,0;AN=2 GT 0|0
chr7 99770202 rs55951658 T A,C . PASS PX=CYP3A4;AC=0,0;AN=2 GT 0|0
chr7 99770217 rs1449865051 A T . PASS PX=CYP3A4;AC=0;AN=2 GT 0|0
chr7 99778079 rs56324128 C T . PASS PX=CYP3A4;AC=0;AN=2 GT 0|0
chr7 99784018 rs570051168 G C . PASS PX=CYP3A4;AC=0;AN=2 GT 0|0
chr7 99784038 rs12721634 A G . PASS PX=CYP3A4;AC=0;AN=2 GT 0|0
chr7 99784075 rs188389063 G C . PASS PX=CYP3A4;AC=0;AN=2 GT 0|0
chr7 99784237 rs59537101 G T . PASS PX=CYP3A4;AC=0;AN=2 GT 0|0
chr7 99784382 rs35223458 A G . PASS PX=CYP3A4;AC=0;AN=2 GT 0|0
chr7 99784450 rs72552802 A C,T . PASS PX=CYP3A4;AC=0,0;AN=2 GT 0|0
chr7 99784473 rs2740574 C A,G,T 10004.8 PASS PX=CYP3A4;AC=0,0,1;AN=2 GT 3|0
chr7 117509035 rs397508256 G A . PASS PX=CFTR;AC=0;AN=2 GT 0|0
chr7 117509069 rs368505753 C T . PASS PX=CFTR;AC=0;AN=2 GT 0|0
chr7 117509089 rs115545701 C T . PASS PX=CFTR;AC=0;AN=2 GT 0|0
chr7 117530953 rs113993958 G C . PASS PX=CFTR;AC=0;AN=2 GT 0|0
chr7 117530955 rs397508537 C A . PASS PX=CFTR;AC=0;AN=2 GT 0|0
chr7 117530974 rs77834169 C T . PASS PX=CFTR;AC=0;AN=2 GT 0|0
chr7 117530975 rs78655421 G A . PASS PX=CFTR;AC=0;AN=2 GT 0|0
chr7 117534318 rs80282562 G A . PASS PX=CFTR;AC=0;AN=2 GT 0|0
chr7 117534363 rs397508759 G A . PASS PX=CFTR;AC=0;AN=2 GT 0|0
chr7 117534368 rs397508761 A G . PASS PX=CFTR;AC=0;AN=2 GT 0|0
chr7 117535285 rs121908752 T G . PASS PX=CFTR;AC=0;AN=2 GT 0|0
chr7 117540270 rs77932196 G A . PASS PX=CFTR;AC=0;AN=2 GT 0|0
chr7 117540285 rs121908753 G A . PASS PX=CFTR;AC=0;AN=2 GT 0|0
chr7 117548795 rs74551128 C A . PASS PX=CFTR;AC=0;AN=2 GT 0|0
chr7 117587799 rs121908757 A C . PASS PX=CFTR;AC=0;AN=2 GT 0|0
chr7 117587800 rs121908755 G A . PASS PX=CFTR;AC=0;AN=2 GT 0|0
chr7 117587801 rs121909005 T G . PASS PX=CFTR;AC=0;AN=2 GT 0|0
chr7 117587805 rs121909013 G A . PASS PX=CFTR;AC=0;AN=2 GT 0|0
chr7 117587806 rs75527207 G A . PASS PX=CFTR;AC=0;AN=2 GT 0|0
chr7 117590409 rs397508288 A G . PASS PX=CFTR;AC=0;AN=2 GT 0|0
chr7 117594930 rs397508387 G T . PASS PX=CFTR;AC=0;AN=2 GT 0|0
chr7 117602868 rs80224560 G A . PASS PX=CFTR;AC=0;AN=2 GT 0|0
chr7 117603708 rs397508442 C T . PASS PX=CFTR;AC=0;AN=2 GT 0|0
chr7 117606695 rs141033578 C T . PASS PX=CFTR;AC=0;AN=2 GT 0|0
chr7 117611555 rs76151804 A G . PASS PX=CFTR;AC=0;AN=2 GT 0|0
chr7 117611595 rs150212784 T G . PASS PX=CFTR;AC=0;AN=2 GT 0|0
chr7 117611620 rs397508513 A C . PASS PX=CFTR;AC=0;AN=2 GT 0|0
chr7 117611640 rs121909020 G A . PASS PX=CFTR;AC=0;AN=2 GT 0|0
chr7 117611646 rs200321110 G A . PASS PX=CFTR;AC=0;AN=2 GT 0|0
chr7 117611649 rs202179988 C T . PASS PX=CFTR;AC=0;AN=2 GT 0|0
chr7 117611650 rs78769542 G A . PASS PX=CFTR;AC=0;AN=2 GT 0|0
chr7 117611663 rs186045772 T A . PASS PX=CFTR;AC=0;AN=2 GT 0|0
chr7 117614699 rs75541969 G C . PASS PX=CFTR;AC=0;AN=2 GT 0|0
chr7 117639961 rs75039782 C T . PASS PX=CFTR;AC=0;AN=2 GT 0|0
chr7 117642451 rs267606723 G A . PASS PX=CFTR;AC=0;AN=2 GT 0|0
chr7 117642472 rs74503330 G A . PASS PX=CFTR;AC=0;AN=2 GT 0|0
chr7 117642483 rs121909041 T C . PASS PX=CFTR;AC=0;AN=2 GT 0|0
chr7 117642528 rs11971167 G A . PASS PX=CFTR;AC=0;AN=2 GT 0|0
chr7 117664770 rs193922525 G A . PASS PX=CFTR;AC=0;AN=2 GT 0|0
chr8 18400032 rs72466456 T A,C,G . PASS PX=NAT2;AC=0,0,0;AN=2 GT 0|0
chr8 18400073 rs45477599 T A,C . PASS PX=NAT2;AC=0,0;AN=2 GT 0|0
chr8 18400114 rs72554615 T C . PASS PX=NAT2;AC=0;AN=2 GT 0|0
chr8 18400155 rs72466457 G T . PASS PX=NAT2;AC=0;AN=2 GT 0|0
chr8 18400193 rs1805158 C A,T . PASS PX=NAT2;AC=0,0;AN=2 GT 0|0
chr8 18400194 rs1801279 G A 14865.8 PASS AC=1;AF=0.5;AN=2;BaseQRankSum=6.151;ClippingRankSum=0;DB;DP=1288;ExcessHet=3.0103;FS=1.097;MLEAC=1;MLEAF=0.5;MQ=60;MQRankSum=0;QD=11.6;ReadPosRankSum=0.597;SOR=0.79 GT:AD:DP:GQ:PL 0/1:654,627:1281:99:14894,0,14458
chr8 18400206 rs72466458 G A . PASS PX=NAT2;AC=0;AN=2 GT 0|0
chr8 18400229 226T>G T G . PASS PX=NAT2;AC=0;AN=2 GT 0|0
chr8 18400231 rs72466459 C A,G,T . PASS PX=NAT2;AC=0,0,0;AN=2 GT 0|0
chr8 18400285 rs1041983 C T 14476.8 PASS AC=1;AF=0.5;AN=2;BaseQRankSum=-4.297;ClippingRankSum=0;DB;DP=1218;ExcessHet=3.0103;FS=1.72;MLEAC=1;MLEAF=0.5;MQ=60;MQRankSum=0;QD=11.93;ReadPosRankSum=-0.09;SOR=0.637 GT:AD:DP:GQ:PL 0/1:600,613:1213:99:14505,0,14733
chr8 18400311 308C>T C T . PASS PX=NAT2;AC=0;AN=2 GT 0|0
chr8 18400344 rs1801280 T A,C . PASS PX=NAT2;AC=0,0;AN=2 GT 0|0
chr8 18400348 rs45532639 C T . PASS PX=NAT2;AC=0;AN=2 GT 0|0
chr8 18400367 rs4986996 G A,C,T . PASS PX=NAT2;AC=0,0,0;AN=2 GT 0|0
chr8 18400406 rs12720065 C G . PASS PX=NAT2;AC=0;AN=2 GT 0|0
chr8 18400414 rs4986997 A C,T . PASS PX=NAT2;AC=0,0;AN=2 GT 0|0
chr8 18400437 rs72554616 A C . PASS PX=NAT2;AC=0;AN=2 GT 0|0
chr8 18400461 rs72466460 C T . PASS PX=NAT2;AC=0;AN=2 GT 0|0
chr8 18400475 rs139351995 A C . PASS PX=NAT2;AC=0;AN=2 GT 0|0
chr8 18400484 rs1799929 C T . PASS PX=NAT2;AC=0;AN=2 GT 0|0
chr8 18400502 rs72554617 G A,C . PASS PX=NAT2;AC=0,0;AN=2 GT 0|0
chr8 18400521 518A>G A G . PASS PX=NAT2;AC=0;AN=2 GT 0|0
chr8 18400581 rs79050330 C T . PASS PX=NAT2;AC=0;AN=2 GT 0|0
chr8 18400593 rs1799930 G A,C . PASS PX=NAT2;AC=0,0;AN=2 GT 0|0
chr8 18400603 rs72466461 A G . PASS PX=NAT2;AC=0;AN=2 GT 0|0
chr8 18400612 rs45618543 G A,C,T . PASS PX=NAT2;AC=0,0,0;AN=2 GT 0|0
chr8 18400625 rs56387565 T C . PASS PX=NAT2;AC=0;AN=2 GT 0|0
chr8 18400636 633G>A G A . PASS PX=NAT2;AC=0;AN=2 GT 0|0
chr8 18400641 rs138707146 C T . PASS PX=NAT2;AC=0;AN=2 GT 0|0
chr8 18400668 665T>G T G . PASS PX=NAT2;AC=0;AN=2 GT 0|0
chr8 18400686 rs45518335 C T . PASS PX=NAT2;AC=0;AN=2 GT 0|0
chr8 18400762 rs56011192 C T . PASS PX=NAT2;AC=0;AN=2 GT 0|0
chr8 18400769 rs55700793 A G,T . PASS PX=NAT2;AC=0,0;AN=2 GT 0|0
chr8 18400806 rs1208 G A,C,T 7841.77 PASS AC=1,0,0;AF=0.5,.,.;AN=2;BaseQRankSum=-0.731;ClippingRankSum=0;DB;DP=662;ExcessHet=3.0103;FS=0.524;MLEAC=1,.,.;MLEAF=0.5,.,.;MQ=60;MQRankSum=0;QD=11.97;ReadPosRankSum=-1.662;SOR=0.634 GT:AD:DP:GQ:PL 0/1:323,332,.,.:655:99:7870,0,7451,.,.,.,.,.,.,.
chr8 18400841 rs56393504 G A,T . PASS PX=NAT2;AC=0,0;AN=2 GT 0|0
chr8 18400848 rs56054745 A C,G . PASS PX=NAT2;AC=0,0;AN=2 GT 0|0
chr8 18400860 rs1799931 G A . PASS PX=NAT2;AC=0;AN=2 GT 0|0
chr8 18400861 859Del AT A . PASS PX=NAT2;AC=0;AN=2 GT 0|0
chr10 94645745 rs12777823 G A . PASS POI;AC=0;AN=2 GT 0|0
chr10 94761900 rs12248560 C T 7403.77 PASS AC=1;AF=0.5;AN=2;BaseQRankSum=-2.068;ClippingRankSum=0;DB;DP=820;ExcessHet=3.0103;FS=2.477;MLEAC=1;MLEAF=0.5;MQ=60;MQRankSum=0;QD=9.1;ReadPosRankSum=-1.08;SOR=0.89 GT:AD:DP:GQ:PL 0/1:462,352:814:99:7432,0,10951
chr10 94762706 rs28399504 A G . PASS PX=CYP2C19;AC=0;AN=2 GT 0|0
chr10 94762712 rs367543002 C T . PASS PX=CYP2C19;AC=0;AN=2 GT 0|0
chr10 94762715 rs367543003 T C . PASS PX=CYP2C19;AC=0;AN=2 GT 0|0
chr10 94762755 rs55752064 T C . PASS PX=CYP2C19;AC=0;AN=2 GT 0|0
chr10 94762760 rs17882687 A C . PASS PX=CYP2C19;AC=0;AN=2 GT 0|0
chr10 94762788 rs1564656981 A T . PASS PX=CYP2C19;AC=0;AN=2 GT 0|0
chr10 94762856 rs1564657013 A G . PASS PX=CYP2C19;AC=0;AN=2 GT 0|0
chr10 94775106 rs145328984 C T . PASS PX=CYP2C19;AC=0;AN=2 GT 0|0
chr10 94775121 rs1564660997 C T . PASS PX=CYP2C19;AC=0;AN=2 GT 0|0
chr10 94775160 rs118203756 G C . PASS PX=CYP2C19;AC=0;AN=2 GT 0|0
chr10 94775185 rs1288601658 A G . PASS PX=CYP2C19;AC=0;AN=2 GT 0|0
chr10 94775367 rs12769205 A G . PASS PX=CYP2C19;AC=0;AN=2 GT 0|0
chr10 94775416 rs41291556 T C . PASS PX=CYP2C19;AC=0;AN=2 GT 0|0
chr10 94775423 rs17885179 A C . PASS PX=CYP2C19;AC=0;AN=2 GT 0|0
chr10 94775453 rs72552267 G A . PASS PX=CYP2C19;AC=0;AN=2 GT 0|0
chr10 94775489 rs17884712 G A . PASS PX=CYP2C19;AC=0;AN=2 GT 0|0
chr10 94775507 rs58973490 G A . PASS PX=CYP2C19;AC=0;AN=2 GT 0|0
chr10 94780574 rs140278421 G C . PASS PX=CYP2C19;AC=0;AN=2 GT 0|0
chr10 94780579 rs370803989 G A . PASS PX=CYP2C19;AC=0;AN=2 GT 0|0
chr10 94780653 rs4986893 G A . PASS PX=CYP2C19;AC=0;AN=2 GT 0|0
chr10 94781858 rs6413438 C T . PASS PX=CYP2C19;AC=0;AN=2 GT 0|0
chr10 94781859 rs4244285 G A . PASS PX=CYP2C19;AC=0;AN=2 GT 0|0
chr10 94781944 rs375781227 G A . PASS PX=CYP2C19;AC=0;AN=2 GT 0|0
chr10 94781999 rs72558186 T A . PASS PX=CYP2C19;AC=0;AN=2 GT 0|0
chr10 94842861 rs138142612 G A . PASS PX=CYP2C19;AC=0;AN=2 GT 0|0
chr10 94842866 rs3758581 A G 34517.8 PASS AC=2;AF=1;AN=2;DP=1219;ExcessHet=3.0103;FS=0;MLEAC=2;MLEAF=1;MQ=59.99;QD=28.55;SOR=1.07 GT:AD:DP:GQ:PL 1/1:0,1209:1209:99:34546,3625,0
chr10 94842879 rs118203757 G A . PASS PX=CYP2C19;AC=0;AN=2 GT 0|0
chr10 94842995 rs113934938 G A . PASS PX=CYP2C19;AC=0;AN=2 GT 0|0
chr10 94849995 rs17879685 C T 9489.77 PASS AC=1;AF=0.5;AN=2;BaseQRankSum=2.488;ClippingRankSum=0;DB;DP=976;ExcessHet=3.0103;FS=0.522;MLEAC=1;MLEAF=0.5;MQ=59.96;MQRankSum=-1.103;QD=9.75;ReadPosRankSum=1.632;SOR=0.748 GT:AD:DP:GQ:PL 0/1:535,438:973:99:9518,0,11831
chr10 94852738 rs56337013 C T . PASS PX=CYP2C19;AC=0;AN=2 GT 0|0
chr10 94852765 rs192154563 C T . PASS PX=CYP2C19;AC=0;AN=2 GT 0|0
chr10 94852785 rs118203759 C G . PASS PX=CYP2C19;AC=0;AN=2 GT 0|0
chr10 94852914 rs55640102 A C . PASS PX=CYP2C19;AC=0;AN=2 GT 0|0
chr10 94938683 rs114071557 A G . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94938719 . T G . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94938737 rs67807361 C A . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94938771 rs142240658 C T . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94938788 . C T . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94938800 rs1364419386 G A . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94938803 rs2031308986 A G . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94938828 rs564813580 A G . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94941897 rs371055887 G C . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94941915 . G A . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94941958 rs72558187 T C . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94941975 . G A . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94941976 . G C . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94941982 rs762239445 G T . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94942018 . T C . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94942205 rs1304490498 CAATGGAAAGA C . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94942216 rs774607211 A G . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94942230 rs767576260 C T . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94942231 rs12414460 G A . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94942233 rs375805362 C T . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94942234 rs72558189 G A,T . PASS PX=CYP2C9;AC=0,0;AN=2 GT 0|0
chr10 94942243 rs1375956433 T G . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94942249 rs200965026 C G,T . PASS PX=CYP2C9;AC=0,0;AN=2 GT 0|0
chr10 94942254 rs199523631 C T . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94942255 rs200183364 G A . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94942290 rs1799853 C T . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94942291 rs141489852 G A . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94942305 rs754487195 G A . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94942306 rs1289704600 C T . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94942308 rs17847037 C T . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94942309 rs7900194 G A,T . PASS PX=CYP2C9;AC=0,0;AN=2 GT 0|0
chr10 94947782 rs72558190 C A . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94947785 rs774550549 C T . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94947869 . A G . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94947907 . A C . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94947917 rs1326630788 T C . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94947938 rs2031531005 A T . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94947939 rs370100007 G T . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94949129 . A G . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94949144 . C T . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94949145 rs772782449 C T . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94949161 . AT A . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94949217 rs2256871 A G . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94949280 rs9332130 A G . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94949281 rs9332131 GA G . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94972119 rs182132442 C A . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94972123 . C G . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94972134 . A G . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94972179 rs72558192 A G . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94972180 rs988617574 C G . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94972183 . A T . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94972233 rs1237225311 C T . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94981199 . G T . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94981201 rs57505750 T C . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94981224 rs28371685 C T . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94981225 rs367826293 G A . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94981230 rs1274535931 C A . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94981250 rs750820937 C A . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94981258 rs1297714792 C T . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94981281 rs749060448 G A . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94981296 rs1057910 A C . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94981297 rs56165452 T C . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94981301 rs28371686 C G . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94981302 rs1250577724 C A . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94981305 rs578144976 C G . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94981365 . C T . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94981371 rs542577750 G A . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94986042 rs764211126 A G . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94986073 rs72558193 A C . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94986136 rs1254213342 A C . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94986174 rs1441296358 G C . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94988852 rs776908257 C T . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94988855 . A T . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94988880 . G T . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94988917 rs769942899 G C . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94988925 rs202201137 A G . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94988955 rs767284820 T C . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94988984 rs781583846 G A . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94989020 rs9332239 C T . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 94989023 rs868182778 G T . PASS PX=CYP2C9;AC=0;AN=2 GT 0|0
chr10 95037039 rs28399518 G A . PASS PX=CYP2C8;AC=0;AN=2 GT 0|0
chr10 95037074 rs761474363 T TA . PASS PX=CYP2C8;AC=0;AN=2 GT 0|0
chr10 95037104 rs1058932 G A,C . PASS PX=CYP2C8;AC=0,0;AN=2 GT 0|0
chr10 95037216 rs3832694 TCAA TCAACAA,T . PASS PX=CYP2C8;AC=0,0;AN=2 GT 0|0
chr10 95038958 rs148515896 G A,T . PASS PX=CYP2C8;AC=0,0;AN=2 GT 0|0
chr10 95038992 rs10509681 T C . PASS PX=CYP2C8;AC=0;AN=2 GT 0|0
chr10 95042890 c.939G>T C A . PASS PX=CYP2C8;AC=0;AN=2 GT 0|0
chr10 95042958 rs45438799 G A,T . PASS PX=CYP2C8;AC=0,0;AN=2 GT 0|0
chr10 95042980 rs11188150 G A . PASS PX=CYP2C8;AC=0;AN=2 GT 0|0
chr10 95043047 rs146806199 A C,G . PASS PX=CYP2C8;AC=0,0;AN=2 GT 0|0
chr10 95045835 rs200154618 G A,T . PASS PX=CYP2C8;AC=0,0;AN=2 GT 0|0
chr10 95045951 rs78637571 C A,G . PASS PX=CYP2C8;AC=0,0;AN=2 GT 0|0
chr10 95058349 rs11572103 T A,G . PASS PX=CYP2C8;AC=0,0;AN=2 GT 0|0
chr10 95058362 rs1058930 G A,C . PASS PX=CYP2C8;AC=0,0;AN=2 GT 0|0
chr10 95058414 rs769460274 T C . PASS PX=CYP2C8;AC=0;AN=2 GT 0|0
chr10 95058424 rs11572102 T A,C . PASS PX=CYP2C8;AC=0,0;AN=2 GT 0|0
chr10 95058442 rs188934928 C G . PASS PX=CYP2C8;AC=0;AN=2 GT 0|0
chr10 95058485 c.459T>G A C . PASS PX=CYP2C8;AC=0;AN=2 GT 0|0
chr10 95064886 rs72558195 G A,C . PASS PX=CYP2C8;AC=0,0;AN=2 GT 0|0
chr10 95064901 rs41286886 C T . PASS PX=CYP2C8;AC=0;AN=2 GT 0|0
chr10 95064931 rs142886225 C T . PASS PX=CYP2C8;AC=0;AN=2 GT 0|0
chr10 95067209 rs11572081 C G,T . PASS PX=CYP2C8;AC=0,0;AN=2 GT 0|0
chr10 95067213 rs72558196 GT G . PASS PX=CYP2C8;AC=0;AN=2 GT 0|0
chr10 95067273 rs11572080 C A,T . PASS PX=CYP2C8;AC=0,0;AN=2 GT 0|0
chr10 95069408 rs142144821 C G,T . PASS PX=CYP2C8;AC=0,0;AN=2 GT 0|0
chr10 95069488 rs11572066 T C,G . PASS PX=CYP2C8;AC=0,0;AN=2 GT 0|0
chr10 95069524 rs547978262 T G . PASS PX=CYP2C8;AC=0;AN=2 GT 0|0
chr10 95069535 rs78041161 T G . PASS PX=CYP2C8;AC=0;AN=2 GT 0|0
chr10 95069649 rs11572065 A AT . PASS PX=CYP2C8;AC=0;AN=2 GT 0|0
chr10 95069673 rs7909236 G T . PASS PX=CYP2C8;AC=0;AN=2 GT 0|0
chr10 95069772 rs17110453 A C,T . PASS PX=CYP2C8;AC=0,0;AN=2 GT 0|0
chr10 95069813 rs7912549 G A . PASS PX=CYP2C8;AC=0;AN=2 GT 0|0
chr12 21172734 rs139257324 C T . PASS PX=SLCO1B1;AC=0;AN=2 GT 0|0
chr12 21172776 rs373327528 G A . PASS PX=SLCO1B1;AC=0;AN=2 GT 0|0
chr12 21172782 rs56101265 T C . PASS PX=SLCO1B1;AC=0;AN=2 GT 0|0
chr12 21174595 rs56061388 T C . PASS PX=SLCO1B1;AC=0;AN=2 GT 0|0
chr12 21176804 rs2306283 A G . PASS PX=SLCO1B1;AC=0;AN=2 GT 0|0
chr12 21176868 rs2306282 A G . PASS PX=SLCO1B1;AC=0;AN=2 GT 0|0
chr12 21176871 . G A . PASS PX=SLCO1B1;AC=0;AN=2 GT 0|0
chr12 21176879 rs11045819 C A . PASS PX=SLCO1B1;AC=0;AN=2 GT 0|0
chr12 21176883 rs72559745 A G . PASS PX=SLCO1B1;AC=0;AN=2 GT 0|0
chr12 21176898 rs77271279 G T . PASS PX=SLCO1B1;AC=0;AN=2 GT 0|0
chr12 21178612 rs141467543 A G . PASS PX=SLCO1B1;AC=0;AN=2 GT 0|0
chr12 21178615 rs4149056 T C . PASS PX=SLCO1B1;AC=0;AN=2 GT 0|0
chr12 21178957 rs79135870 A G . PASS PX=SLCO1B1;AC=0;AN=2 GT 0|0
chr12 21196951 rs11045852 A G . PASS PX=SLCO1B1;AC=0;AN=2 GT 0|0
chr12 21196975 rs183501729 C T . PASS PX=SLCO1B1;AC=0;AN=2 GT 0|0
chr12 21196976 rs11045853 G A . PASS PX=SLCO1B1;AC=0;AN=2 GT 0|0
chr12 21200544 rs72559747 C G . PASS PX=SLCO1B1;AC=0;AN=2 GT 0|0
chr12 21200595 rs55901008 T C . PASS PX=SLCO1B1;AC=0;AN=2 GT 0|0
chr12 21202553 rs1228465562 T G . PASS PX=SLCO1B1;AC=0;AN=2 GT 0|0
chr12 21202555 rs59113707 C G . PASS PX=SLCO1B1;AC=0;AN=2 GT 0|0
chr12 21202649 rs56387224 A G . PASS PX=SLCO1B1;AC=0;AN=2 GT 0|0
chr12 21202664 rs142965323 G A . PASS PX=SLCO1B1;AC=0;AN=2 GT 0|0
chr12 21205921 rs72559748 A G . PASS PX=SLCO1B1;AC=0;AN=2 GT 0|0
chr12 21205999 rs59502379 G C . PASS PX=SLCO1B1;AC=0;AN=2 GT 0|0
chr12 21206031 rs74064213 A G . PASS PX=SLCO1B1;AC=0;AN=2 GT 0|0
chr12 21222355 rs71581941 C T . PASS PX=SLCO1B1;AC=0;AN=2 GT 0|0
chr12 21239042 rs34671512 A C . PASS PX=SLCO1B1;AC=0;AN=2 GT 0|0
chr12 21239077 rs56199088 A G . PASS PX=SLCO1B1;AC=0;AN=2 GT 0|0
chr12 21239113 rs55737008 A G . PASS PX=SLCO1B1;AC=0;AN=2 GT 0|0
chr12 21239145 rs200995543 C T . PASS PX=SLCO1B1;AC=0;AN=2 GT 0|0
chr12 21239158 rs140790673 C T . PASS PX=SLCO1B1;AC=0;AN=2 GT 0|0
chr13 48037748 rs769369441 T C . PASS PX=NUDT15;AC=0;AN=2 GT 0|0
chr13 48037749 . G C . PASS PX=NUDT15;AC=0;AN=2 GT 0|0
chr13 48037782 rs746071566 AGGAGTC AGGAGTCGGAGTC,A . PASS PX=NUDT15;AC=0,0;AN=2 GT 0|0
chr13 48037798 rs186364861 G A . PASS PX=NUDT15;AC=0;AN=2 GT 0|0
chr13 48037825 rs777311140 C CGCGG . PASS PX=NUDT15;AC=0;AN=2 GT 0|0
chr13 48037834 rs1202487323 C T . PASS PX=NUDT15;AC=0;AN=2 GT 0|0
chr13 48037847 rs766023281 G C . PASS PX=NUDT15;AC=0;AN=2 GT 0|0
chr13 48037849 . A G . PASS PX=NUDT15;AC=0;AN=2 GT 0|0
chr13 48037885 rs1950545307 G A . PASS PX=NUDT15;AC=0;AN=2 GT 0|0
chr13 48037902 rs149436418 C G . PASS PX=NUDT15;AC=0;AN=2 GT 0|0
chr13 48040977 rs1457579126 GA G . PASS PX=NUDT15;AC=0;AN=2 GT 0|0
chr13 48041103 rs761191455 T TG . PASS PX=NUDT15;AC=0;AN=2 GT 0|0
chr13 48041113 rs1368252918 G T . PASS PX=NUDT15;AC=0;AN=2 GT 0|0
chr13 48045690 rs768324690 C G . PASS PX=NUDT15;AC=0;AN=2 GT 0|0
chr13 48045719 rs116855232 C T . PASS PX=NUDT15;AC=0;AN=2 GT 0|0
chr13 48045720 rs147390019 G A . PASS PX=NUDT15;AC=0;AN=2 GT 0|0
chr13 48045771 rs139551410 T A . PASS PX=NUDT15;AC=0;AN=2 GT 0|0
chr16 31096368 rs9923231 C T . PASS PX=VKORC1;AC=0;AN=2 GT 0|0
chr19 15879621 rs2108622 C T . PASS PX=CYP4F2;AC=0;AN=2 GT 0|0
chr19 15897578 rs3093105 A C . PASS PX=CYP4F2;AC=0;AN=2 GT 0|0
chr19 38440802 rs193922747 T C . PASS PX=RYR1;AC=0;AN=2 GT 0|0
chr19 38440829 rs193922748 C T . PASS PX=RYR1;AC=0;AN=2 GT 0|0
chr19 38444211 rs118192161 C T . PASS PX=RYR1;AC=0;AN=2 GT 0|0
chr19 38444212 rs193922753 G T . PASS PX=RYR1;AC=0;AN=2 GT 0|0
chr19 38446710 rs1801086 G A,C . PASS PX=RYR1;AC=0,0;AN=2 GT 0|0
chr19 38448673 rs193922762 C T . PASS PX=RYR1;AC=0;AN=2 GT 0|0
chr19 38448712 rs121918592 G A,C . PASS PX=RYR1;AC=0,0;AN=2 GT 0|0
chr19 38451842 rs193922764 C T . PASS PX=RYR1;AC=0;AN=2 GT 0|0
chr19 38451850 rs118192116 C G . PASS PX=RYR1;AC=0;AN=2 GT 0|0
chr19 38455359 rs118192162 A C . PASS PX=RYR1;AC=0;AN=2 GT 0|0
chr19 38455463 rs111888148 G A . PASS PX=RYR1;AC=0;AN=2 GT 0|0
chr19 38455471 rs193922768 C T . PASS PX=RYR1;AC=0;AN=2 GT 0|0
chr19 38455472 rs144336148 G A . PASS PX=RYR1;AC=0;AN=2 GT 0|0
chr19 38455528 rs193922770 C T . PASS PX=RYR1;AC=0;AN=2 GT 0|0
chr19 38457545 rs118192172 C T . PASS PX=RYR1;AC=0;AN=2 GT 0|0
chr19 38457546 rs193922772 G T . PASS PX=RYR1;AC=0;AN=2 GT 0|0
chr19 38494564 rs118192175 C T . PASS PX=RYR1;AC=0;AN=2 GT 0|0
chr19 38494565 rs118192163 G A . PASS PX=RYR1;AC=0;AN=2 GT 0|0
chr19 38494579 rs118192176 G A . PASS PX=RYR1;AC=0;AN=2 GT 0|0
chr19 38496283 rs118192177 C G,T . PASS PX=RYR1;AC=0,0;AN=2 GT 0|0
chr19 38499223 rs112563513 G A . PASS PX=RYR1;AC=0;AN=2 GT 0|0
chr19 38499644 rs121918596 TGGA T . PASS PX=RYR1;AC=0;AN=2 GT 0|0
chr19 38499655 rs193922802 G A . PASS PX=RYR1;AC=0;AN=2 GT 0|0
chr19 38499670 rs193922803 C T . PASS PX=RYR1;AC=0;AN=2 GT 0|0
chr19 38499731 rs193922807 G C . PASS PX=RYR1;AC=0;AN=2 GT 0|0
chr19 38499975 rs193922809 G A . PASS PX=RYR1;AC=0;AN=2 GT 0|0
chr19 38499993 rs121918593 G A . PASS PX=RYR1;AC=0;AN=2 GT 0|0
chr19 38499997 rs28933396 G A . PASS PX=RYR1;AC=0;AN=2 GT 0|0
chr19 38500636 rs118192124 C T . PASS PX=RYR1;AC=0;AN=2 GT 0|0
chr19 38500642 rs193922816 C T . PASS PX=RYR1;AC=0;AN=2 GT 0|0
chr19 38500643 rs118192122 G A . PASS PX=RYR1;AC=0;AN=2 GT 0|0
chr19 38500654 rs28933397 C T . PASS PX=RYR1;AC=0;AN=2 GT 0|0
chr19 38500655 rs121918594 G A . PASS PX=RYR1;AC=0;AN=2 GT 0|0
chr19 38500898 rs118192178 C G,T . PASS PX=RYR1;AC=0,0;AN=2 GT 0|0
chr19 38500899 rs193922818 G A . PASS PX=RYR1;AC=0;AN=2 GT 0|0
chr19 38512321 rs193922832 G A . PASS PX=RYR1;AC=0;AN=2 GT 0|0
chr19 38543832 rs193922843 G T . PASS PX=RYR1;AC=0;AN=2 GT 0|0
chr19 38580004 rs118192167 A G . PASS PX=RYR1;AC=0;AN=2 GT 0|0
chr19 38580094 rs121918595 C T . PASS PX=RYR1;AC=0;AN=2 GT 0|0
chr19 38580114 rs193922876 C T . PASS PX=RYR1;AC=0;AN=2 GT 0|0
chr19 38580370 rs193922878 C G . PASS PX=RYR1;AC=0;AN=2 GT 0|0
chr19 38580403 rs118192168 G A . PASS PX=RYR1;AC=0;AN=2 GT 0|0
chr19 38580440 rs63749869 G A . PASS PX=RYR1;AC=0;AN=2 GT 0|0
chr19 38584989 rs118192170 T C . PASS PX=RYR1;AC=0;AN=2 GT 0|0
chr19 39248147 rs12979860 C T 18258.8 PASS AC=1;AF=0.5;AN=2;BaseQRankSum=-0.124;ClippingRankSum=0;DB;DP=1589;ExcessHet=3.0103;FS=0.521;MLEAC=1;MLEAF=0.5;MQ=59.91;MQRankSum=-3.295;QD=11.58;ReadPosRankSum=1.662;SOR=0.667 GT:AD:DP:GQ:PL 0/1:781,796:1577:99:18287,0,17773
chr19 40991224 rs34223104 T C . PASS PX=CYP2B6;AC=0;AN=2 GT 0|0
chr19 40991367 rs34883432 A T . PASS PX=CYP2B6;AC=0;AN=2 GT 0|0
chr19 40991369 rs8192709 C T . PASS PX=CYP2B6;AC=0;AN=2 GT 0|0
chr19 40991381 rs33973337 A T . PASS PX=CYP2B6;AC=0;AN=2 GT 0|0
chr19 40991388 rs33980385 A G . PASS PX=CYP2B6;AC=0;AN=2 GT 0|0
chr19 40991390 rs33926104 C A . PASS PX=CYP2B6;AC=0;AN=2 GT 0|0
chr19 40991391 rs34284776 G C . PASS PX=CYP2B6;AC=0;AN=2 GT 0|0
chr19 40991441 rs35303484 A G . PASS PX=CYP2B6;AC=0;AN=2 GT 0|0
chr19 41004015 rs281864907 T A . PASS PX=CYP2B6;AC=0;AN=2 GT 0|0
chr19 41004125 rs36060847 G A . PASS PX=CYP2B6;AC=0;AN=2 GT 0|0
chr19 41004158 rs186335453 G T . PASS PX=CYP2B6;AC=0;AN=2 GT 0|0
chr19 41004303 rs139801276 T C . PASS PX=CYP2B6;AC=0;AN=2 GT 0|0
chr19 41004377 rs12721655 A G . PASS PX=CYP2B6;AC=0;AN=2 GT 0|0
chr19 41004381 rs35773040 G A . PASS PX=CYP2B6;AC=0;AN=2 GT 0|0
chr19 41004406 rs145884402 G T . PASS PX=CYP2B6;AC=0;AN=2 GT 0|0
chr19 41006919 rs3826711 C G . PASS PX=CYP2B6;AC=0;AN=2 GT 0|0
chr19 41006923 rs36056539 C T . PASS PX=CYP2B6;AC=0;AN=2 GT 0|0
chr19 41006936 rs3745274 G T 13014.8 PASS AC=1;AF=0.5;AN=2;BaseQRankSum=-1.722;ClippingRankSum=0;DB;DP=1269;ExcessHet=3.0103;FS=0.517;MLEAC=1;MLEAF=0.5;MQ=59.88;MQRankSum=-3.047;QD=10.33;ReadPosRankSum=1.289;SOR=0.762 GT:AD:DP:GQ:PL 0/1:656,604:1260:99:13043,0,14774
chr19 41006968 rs373489637 T G . PASS PX=CYP2B6;AC=0;AN=2 GT 0|0
chr19 41007013 rs36079186 T C . PASS PX=CYP2B6;AC=0;AN=2 GT 0|0
chr19 41009350 rs45482602 C A . PASS PX=CYP2B6;AC=0;AN=2 GT 0|0
chr19 41009358 rs2279343 A G 2666.77 PASS AC=1;AF=0.5;AN=2;BaseQRankSum=10.445;ClippingRankSum=0;DB;DP=843;ExcessHet=3.0103;FS=3.355;MLEAC=1;MLEAF=0.5;MQ=54.61;MQRankSum=-21.472;QD=3.16;ReadPosRankSum=-2.643;SOR=0.824 GT:AD:DP:GQ:PL 0/1:686,157:843:99:2695,0,17020
chr19 41010006 rs139029625 G C . PASS PX=CYP2B6;AC=0;AN=2 GT 0|0
chr19 41010088 rs34698757 C G . PASS PX=CYP2B6;AC=0;AN=2 GT 0|0
chr19 41010108 rs193922917 C A . PASS PX=CYP2B6;AC=0;AN=2 GT 0|0
chr19 41012316 rs28399499 T C . PASS PX=CYP2B6;AC=0;AN=2 GT 0|0
chr19 41012339 rs34826503 C T . PASS PX=CYP2B6;AC=0;AN=2 GT 0|0
chr19 41012465 rs34097093 C T . PASS PX=CYP2B6;AC=0;AN=2 GT 0|0
chr19 41012693 rs35979566 T A . PASS PX=CYP2B6;AC=0;AN=2 GT 0|0
chr19 41012740 rs193922918 G A . PASS PX=CYP2B6;AC=0;AN=2 GT 0|0
chr19 41012803 rs35010098 C A . PASS PX=CYP2B6;AC=0;AN=2 GT 0|0
chr19 41016726 rs3211369 A G . PASS PX=CYP2B6;AC=0;AN=2 GT 0|0
chr19 41016778 rs564083989 G A . PASS PX=CYP2B6;AC=0;AN=2 GT 0|0
chr19 41016805 . A T . PASS PX=CYP2B6;AC=0;AN=2 GT 0|0
chr19 41016810 rs3211371 C A,T . PASS PX=CYP2B6;AC=0,0;AN=2 GT 0|0
chr22 42126578 rs1440526469 C T . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42126605 rs568495591 G A . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42126611 rs1135840 C G 24060.8 PASS AC=1;AF=0.5;AN=2;BaseQRankSum=-8.19;ClippingRankSum=0;DP=2073;ExcessHet=3.0103;FS=0;MLEAC=1;MLEAF=0.5;MQ=59.61;MQRankSum=-9.41;QD=11.67;ReadPosRankSum=0.445;SOR=0.653 GT:AD:DP:GQ:PL 0/1:1030,1031:2061:99:24089,0,25402
chr22 42126623 rs75467367 G C . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42126624 rs74478221 C T . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42126627 . A C . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42126633 . C G . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42126634 . A C . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42126635 rs766507177 T G . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42126636 rs28371735 G A . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42126647 rs141756339 C T . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42126656 rs765776661 C CCAGTGGGCA . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42126660 rs1135835 T C . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42126663 rs1135833 G C . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42126681 . G C . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42126697 . G T . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42126719 rs369177208 C T . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42126735 rs751092905 C T . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42126746 rs532668079 C T . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42126747 rs730882251 G A . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42126749 rs267608319 C T . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42126752 rs569439709 C T . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42126877 rs3021084 G A . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42126896 rs763964554 G A . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42126914 rs28371733 C T . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42126926 rs747089665 G A . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42126938 rs769157652 C T . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42126956 rs1931013246 T G . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42126980 rs757396767 TGA T . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42127457 rs77312092 C T . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42127473 rs75386357 C T . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42127512 rs61745683 C T 37666.8 PASS AC=1;AF=0.5;AN=2;BaseQRankSum=-7.886;ClippingRankSum=0;DB;DP=2839;ExcessHet=3.0103;FS=0;MLEAC=1;MLEAF=0.5;MQ=55.2;MQRankSum=-20.634;QD=13.31;ReadPosRankSum=7.765;SOR=0.737 GT:AD:DP:GQ:PL 0/1:1785,1044:2829:99:37695,0,70549
chr22 42127514 . A G . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42127523 rs1555888910 A G . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42127526 rs1058172 C T . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42127531 rs72549346 CAC A . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42127556 rs202102799 T C . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42127565 rs61736517 T C . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42127589 rs76088846 C T . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42127590 rs72549347 G A . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42127593 rs267608295 G C . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42127602 . C T . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42127608 rs59421388 C T . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42127610 rs748712690 T C . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42127611 rs78209835 C T . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42127619 rs72549348 T G . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42127631 rs141009491 C G . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42127803 rs28371725 C T . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42127841 rs72549349 C G . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42127845 rs730882170 GCACATCCGGATGTAGGATC G . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42127852 rs79292917 C T . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42127856 rs5030867 T G . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42127899 . T C . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42127922 rs1406719554 A G . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42127938 rs949717872 T G . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42127941 rs16947 G A 22489.8 PASS AC=1;AF=0.5;AN=2;BaseQRankSum=1.069;ClippingRankSum=0;DP=1893;ExcessHet=3.0103;FS=0.521;MLEAC=1;MLEAF=0.5;MQ=59.99;MQRankSum=0;QD=11.94;ReadPosRankSum=-0.005;SOR=0.659 GT:AD:DP:GQ:PL 0/1:957,926:1883:99:22518,0,23105
chr22 42127962 rs267608279 TG T . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42127973 rs1135829 T C . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42128173 rs5030656 CCTT C . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42128181 rs1135828 A T . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42128185 rs77913725 C T . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42128198 rs72549351 CTCAG C . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42128211 rs72549352 C CG . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42128212 rs367543000 G A . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42128217 rs148769737 G T . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42128235 rs267608297 G A . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42128241 rs35742686 CT C . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42128248 rs72549353 CAGTT C . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42128272 . T G . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42128308 rs28371717 C A . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42128325 rs17002853 A G . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42128329 rs373813287 G A . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42128351 rs377725912 C T . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42128795 . AG A . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42128812 rs199535154 A G . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42128813 rs150163869 G A . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42128814 rs72549354 T TC . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42128848 rs745365204 C T . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42128878 . C A . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42128879 . A G . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42128904 . CACG TA . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42128927 rs72549356 T TGGGGCGAAA,TGGGGCGAAAGGGGCGAAA . PASS PX=CYP2D6;AC=0,0;AN=2 GT 0|0
chr22 42128945 rs3892097 C T . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42129033 rs5030865 C A,T . PASS PX=CYP2D6;AC=0,0;AN=2 GT 0|0
chr22 42129036 rs1135826 A C . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42129037 rs1135825 G T . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42129042 rs1135824 T C . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42129056 . C G . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42129071 rs267608302 T A,G . PASS PX=CYP2D6;AC=0,0;AN=2 GT 0|0
chr22 42129075 rs28371710 C T . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42129083 rs5030655 CA C . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42129087 rs78482768 G C . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42129098 rs569229126 T C . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42129113 rs375135093 A G . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42129130 rs1058164 C G 28876.8 PASS AC=1;AF=0.5;AN=2;BaseQRankSum=-1.14;ClippingRankSum=0;DP=2480;ExcessHet=3.0103;FS=0;MLEAC=1;MLEAF=0.5;MQ=59.58;MQRankSum=0.748;QD=11.74;ReadPosRankSum=1.648;SOR=0.667 GT:AD:DP:GQ:PL 0/1:1270,1190:2460:99:28905,0,31570
chr22 42129132 rs61736512 C T . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42129134 rs781457579 G A . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42129155 rs1180015037 C T . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42129166 rs766391487 A C . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42129174 rs1135823 C A . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42129180 rs1135822 A T . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42129183 rs374616348 C T . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42129759 rs535642512 C T . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42129765 rs78459009 T C . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42129770 rs28371706 G A,T 25328.8 PASS AC=1,0;AF=0.5,.;AN=2;BaseQRankSum=4.435;ClippingRankSum=0;DB;DP=2184;ExcessHet=3.0103;FS=0.521;MLEAC=1,.;MLEAF=0.5,.;MQ=60;MQRankSum=0;QD=11.67;ReadPosRankSum=0.776;SOR=0.641 GT:AD:DP:GQ:PL 0/1:1118,1052,.:2170:99:25357,0,26780,.,.,.
chr22 42129771 rs74802369 T A . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42129779 rs76187628 A G . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42129780 rs267608308 C T . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42129799 rs76802407 G C . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42129809 rs28371704 T C . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42129819 rs28371703 G T . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42129821 rs267608309 G A . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42129827 rs267608276 C G . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42129836 rs267608310 G A . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42129887 rs1456026511 A C . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42129906 rs267608311 G A . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42129910 rs201377835 C G . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42130654 rs774671100;rs72549357 C CA 34093.7 PASS AC=1;AF=0.5;AN=2;BaseQRankSum=-0.921;ClippingRankSum=0;DB;DP=1801;ExcessHet=3.0103;FS=3.277;MLEAC=1;MLEAF=0.5;MQ=57.22;MQRankSum=-2.05;QD=19.21;ReadPosRankSum=-3.584;SOR=0.488 GT:AD:DP:GQ:PL 0/1:722,1053:1775:99:34131,0,21492
chr22 42130667 rs118203758 C T . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42130668 rs5030862 C T . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42130692 rs1065852 G A . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42130710 rs138100349 G A . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42130715 rs28371696 C T . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42130719 rs267608313 G A . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42130727 . AG A . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42130761 rs769258 C T . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42130773 rs72549358 C T . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0
chr22 42130778 rs773790593 G A . PASS PX=CYP2D6;AC=0;AN=2 GT 0|0

2006
pgx-main/pgx_results/CAN-NA19239-29Mar2025_S32_pgx_result/pharmgkb_annotations.json Normal file
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